Problems of immunopathology and prospects for pharmacotherapy of idiopathic recurrent pericarditis: Using an interleukin 1 inhibitor (Anakinra)
نویسندگان
چکیده
Pericarditis, a clinical syndrome characterized by inflammation and thickening of the pericardium, is one most common forms inflammatory diseases cardiovascular system. The severe complication acute pericarditis idiopathic recurrent (IRP), which has poor prognosis associated with risk cardiac tamponade constrictive pericarditis. pathogenesis complex interaction environmental factors, genetic predisposition, pathological activation innate acquired immunity. Autoinflammatory mechanisms hyperproduction interleukin (IL) 1 attract particular attention. Standard therapy for includes non-steroidal antiinflammatory drugs, colchicine, glucocorticoids, immunosuppressive drugs. A new direction in pharmacotherapy use Anakinra (a recombinant non-glycosylated analog an IL-1 receptor antagonist), blocks signaling IL-1β IL-1α. materials numerous studies are summarized, indicating that effective drug treatment patients IRI who resistant to standard therapy. It assumed wider Anakinra, especially early stages pericarditis, will not only improve prognosis, but also be important identification autoinflammatory phenotype development personalized programs.
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ژورنال
عنوان ژورنال: Nau?no-prakti?eskaâ revmatologiâ
سال: 2023
ISSN: ['1995-4492', '1995-4484']
DOI: https://doi.org/10.47360/1995-4484-2023-47-61